TRIM46¶

Tripartite motif-containing protein 46¶

Description¶

TRIM46-IgG is newly described biomarker of a range of paraneoplastic CNS disorders including cerebellar syndromes, encephalopathy and seizures, limbic encephalitis, brainstem encephalitis, myelopathy, parkinsonism/dystonia.

Mechanism of action¶

Paraneoplastic syndromes

Associated clinical features¶

In an initial series of 22 patients subacute cerebellar syndrome (6 isolated; 9 with CNS accompaniments: encephalopathy (3), brainstem signs (2), myelopathy (2), parkinsonism (1)).

Other phenotypes included limbic encephalitis (3), encephalopathy with/without seizures (2), myelopathy (2).

Associated neoplasia¶

In an initial series of 22 patients, 18 (82%) had cancer:

• Neuroendocrine carcinomas (9)

  • Pancreatic (3)
  • Small-cell lung (4)
  • Oesophagus (1)
  • Endometrium (1)

• Adenocarcinomas (6)

  • Lung (2)
  • Ovarian (2)
  • Endometrial (1)
  • Breast (1)
  • Sarcoma (2)
  • Gastrointestinal tumour (1)

Neurological symptoms in three patients followed immune checkpoint inhibitor (ICI) administration.

See reference.¹

Laboratory method¶

Notes of performance characteristics¶

Grade¶

Next steps¶